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Title: | Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease |
Authors: | Caetano, Ariadiny de Lima Dong-Creste, Káris Ester Gomes, Fábio Agostini do Amaral Silva, Karla Cristina Monteiro da Pesquero, João Bosco Araujo, Mariana da Silva Montor, Wagner Ricardo Viel, Tânia Araújo Buck, Hudson de Sousa |
Keywords: | Alzheimer's disease Amyloid beta B2 receptor Bradykinin Knockout mice |
Issue Date: | Oct-2015 |
Publisher: | Neuropeptides |
Citation: | Caetano AL, Dong-Creste KE, Amaral FA, Monteiro-Silva KC, Pesquero JB, Araujo MS, Montor WR, Viel TA, Buck HS. Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease. Neuropeptides. 2015; 53:51-62. |
Abstract: | Alzheimer's disease (AD) is characterized by cognitive decline, presence of amyloid-beta peptide (Aβ) aggregates and neurofibrillary tangles. Kinins act through B1 and B2 G-protein coupled receptors (B1R and B2R). Chronic infusion of Aβ peptide leads to memory impairment and increases in densities of both kinin receptors in memory processing areas. Similar memory impairment was observed in C57BL/6 mice (WTAβ) but occurred earlier in mice lacking B2R (KOB2Aβ) and was absent in mice lacking B1R (KOB1Aβ). Thus, the aim of this study was to evaluate the participation of B1R and B2R in Aβ peptide induced cognitive deficits through the evaluation of densitiesof kinin receptors, synapses, cell bodies and number of Aβ deposits in brain ofWTAβ, KOB1Aβ and KOB2Aβ mice. An increase in B2R density was observed in both WTAβ and KOB1Aβ in memory processing related areas. KOB1Aβ showed a decrease in neuronal density and an increase in synaptic density and, in addition, an increase in Aβ deposits in KOB2Aβ was observed. In conclusion, memory preservation in KOB1Aβ, could be due to the increase in densities of B2R, suggesting a neuroprotective role for B2R, reinforced by the increased number of Aβ plaques in KOB2Aβ. Our data point to B2R as a potential therapeutic target in AD. |
URI: | https://www.sciencedirect.com/science/article/pii/S0143417915000906?via%3Dihub http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/45 |
ISSN: | 0143-4179 |
Appears in Collections: | Artigos |
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