http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/29 Fri, 13 Mar 2026 00:45:01 GMT 2026-03-13T00:45:01Z http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/55 Title: Circularidade dos médicos nas regiões de saúde no Brasil Authors: Silva, Rodrigo Calado da; Seixas, Paulo Henrique D`Angelo; Viana, Ana Luiza d’Ávila Abstract: Objetivos: caracterizar a circularidade médica no Brasil e a discutir o caso das regiões Norte-Barretos e Sul-Barretos, São Paulo. Métodos: estudo transversal com uso de dados secundários de cadastros nacionais e estudo de caso de uma amostra de médicos nas regiões Norte-Barretos e Sul-Barretos. Resultados: em média, nas regiões de saúde do Brasil, 45% dos médicos em atividades circulam em mais de uma região. As capitais dos estados têm médicos mais estáveis, enquanto que mais de 50% da força de trabalho médica atua em outras regiões. Os profis- sionais com maior tendência de mudança são aqueles que trabalham em especialidades cirúrgicas em serviços para apoiar o diagnóstico e a terapia. Conclusões: há uma alta circulação de médicos entre as regiões, com características distintas entre regiões geográficas e regiões de saúde. No caso de Barretos, os profissionais se movimentam em função de sua associação profissional e de especialidades praticadas. Sun, 01 Jan 2017 00:00:00 GMT http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/55 2017-01-01T00:00:00Z http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/54 Title: Kinin B1 receptor mediates memory impairment in the rat hippocampus Authors: Caetano, Ariadiny de Lima; Dong-Creste, Káris Ester; Baraldi-Tornisielo, Ticiana; Gobeil Jr, Fernand; Montor, Wagner Ricardo; Viel, Tania Araujo; Buck, Hudson de Sousa Abstract: The bradykinin (BK) receptors B1R and B2R are involved in inflammatory responses and their activation can enhance tissue damage. The B2R is constitutively expressed and mediates the physiologic effects of BK, whereas B1R expression is induced after tissue damage. Recently, they have been involved with Alzheimer's disease, ischemic stroke and traumatic brain injury (TBI). In this study, we investigated the role of bradykinin in short and long-term memory consolidation (STM and LTM). It was observed that bilateral injection of BK (300 pmol/μl) disrupted the STM consolidation but not LTM, both evaluated by inhibitory avoidance test. The STM disruption due to BK injection was blocked by the previous injection of the B1R antagonist des-Arg10-HOE140 but not by the B2R antagonist HOE140. Additionally, the injection of the B1 agonist desArg9-BK disrupted STM and LTM consolidation at doses close to physiological concentration of the peptide (2.3 and 37.5 pmol, respectively) which could be reached during tissue injury. The presence of B1R located on glial cells around the implanted guide cannula used for peptide injection was confirmed by immunofluorescence. These data imply in a possible participation of B1R in the STM impairment observed in TBI, neuroinflammation and neurodegeneration. Fri, 01 Apr 2016 00:00:00 GMT http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/54 2016-04-01T00:00:00Z http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/53 Title: Efferent inhibition of otoacoustic emissions in preterm neonates Authors: Durante, Alessandra Spada; Carvallo, Renata Mota Mamede; Sanches, Seisse Gabriela Gandolfi; Ibidi, Silvia Maria; Soares, Jordana Costa Abstract: INTRODUCTION: Abnormalities in auditory function of newborns may occur not only because of preterm birth, but also from the use of medications and from diseases related to prematurity. OBJECTIVE: To analyze the inhibitory effect from stimulation of the olivocochlear efferent system on transient evoked otoacoustic emissions in preterm neonates, comparing these data with those from full-term neonates. METHODS: This was a prospective, cross-sectional, contemporary cohort study with 125 neonates, pooled into two groups: full-term (72 full-term neonates, 36 females and 36 males, born at 37-41 weeks of gestational age); and preterm (53 neonates, 28 males and 25 females, born at ≤36 weeks of gestational age, evaluated at the corrected gestational age of 37-41 weeks). Otoacoustic emissions were recorded using linear and nonlinear click-evoked stimuli, with and without contralateral stimulation. RESULTS: The inhibitory effect of the efferent pathway in otoacoustic emissions was different (p=0.012) between groups, and a mean reduction of 1.48dB SPL in full-term births and of 1.02dB SPL in preterm births was observed for the non-linear click-evoked stimulus. CONCLUSION: The results suggest a reduced inhibitory effect of the olivocochlear efferent system on otoacoustic emissions in preterm neonates. Thu, 01 Oct 2015 00:00:00 GMT http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/53 2015-10-01T00:00:00Z http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/52 Title: Assessment of hearing threshold in adults with hearing loss using an automated system of cortical auditory evoked potential detection Authors: Durante, Alessandra Spada; Wieselberg, Margarita Bernal; Roque, Nayara; Carvalho, Sheila; Pucci, Beatriz; Gudayol, Nicolly; Almeida, Kátia de Abstract: INTRODUCTION: The use of hearing aids by individuals with hearing loss brings a better quality of life. Access to and benefit from these devices may be compromised in patients who present difficulties or limitations in traditional behavioral audiological evaluation, such as newborns and small children, individuals with auditory neuropathy spectrum, autism, and intellectual deficits, and in adults and the elderly with dementia. These populations (or individuals) are unable to undergo a behavioral assessment, and generate a growing demand for objective methods to assess hearing. Cortical auditory evoked potentials have been used for decades to estimate hearing thresholds. Current technological advances have lead to the development of equipment that allows their clinical use, with features that enable greater accuracy, sensitivity, and specificity, and the possibility of automated detection, analysis, and recording of cortical responses. OBJECTIVE: To determine and correlate behavioral auditory thresholds with cortical auditory thresholds obtained from an automated response analysis technique. METHODS: The study included 52 adults, divided into two groups: 21 adults with moderate to severe hearing loss (study group); and 31 adults with normal hearing (control group). An automated system of detection, analysis, and recording of cortical responses (HEARLab®) was used to record the behavioral and cortical thresholds. The subjects remained awake in an acoustically treated environment. Altogether, 150 tone bursts at 500, 1000, 2000, and 4000Hz were presented through insert earphones in descending-ascending intensity. The lowest level at which the subject detected the sound stimulus was defined as the behavioral (hearing) threshold (BT). The lowest level at which a cortical response was observed was defined as the cortical electrophysiological threshold. These two responses were correlated using linear regression. RESULTS: The cortical electrophysiological threshold was, on average, 7.8dB higher than the behavioral for the group with hearing loss and, on average, 14.5dB higher for the group without hearing loss for all studied frequencies. CONCLUSION: The cortical electrophysiological thresholds obtained with the use of an automated response detection system were highly correlated with behavioral thresholds in the group of individuals with hearing loss. Sat, 01 Apr 2017 00:00:00 GMT http://repositorio.fcmsantacasasp.edu.br/jspui/handle/FCMSCSP/52 2017-04-01T00:00:00Z